isolation of a postynaptic blocker from the venom of the green mamba, dendroaspis angusticeps
نویسندگان
چکیده
a blocker of postsynaptic acetylcholine receptors was isolated from venom of the eastern green mamba dendroaspis angusticeps, by gel filtration, ion-exchange and reverse phase high performance liquid chromatography. the isolated component blocks neuromuscular transmission and responses to exogenously applied acetylcholine in isolated chick biventer cervices preparations. these results suggest that postsynaptic blockers exist in venoms of all members of the dendroaspis genus.
منابع مشابه
Isolation of a Postynaptic Blocker from the Venom of the Green Mamba, Dendroaspis angusticeps
A blocker of postsynaptic acetylcholine receptors was isolated from venom of the Eastern green mamba Dendroaspis angusticeps, by gel filtration, ion-exchange and reverse phase high performance liquid chromatography. The isolated component blocks neuromuscular transmission and responses to exogenously applied acetylcholine in isolated chick biventer cervices preparations. These results suggest t...
متن کاملIsolation of a Postsynaptic Blocker from the Venom of the Green Mamba, Dendroaspis Angusticeps
A blocker of postsynaptic acetylcholine receptors was isolated from venom of the Eastern green mamba Dendroaspis angusticeps, by gel filtration, ion-exchange and reverse phase high performance liquid chromatography. The isolated component blocks neuromuscular transmission and responses to exogenously applied acetylcholine in isolated chick biventer cervices preparations. These results suggest t...
متن کاملPeptides with in vitro anti-tumor activity from the venom of the Eastern green mamba, Dendroaspis angusticeps (Elapidae)
Two structurally related (48.6% amino acid sequence identity) peptides with cytotoxic activity against human non-small cell lung adenocarcinoma A549 cells were purified from the venom of the Eastern green mamba Dendroaspis angusticeps using reversed phase HPLC. The peptides were identified as members of the three-finger superfamily of snake toxins by mass fingerprinting of tryptic digests. The ...
متن کاملToxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps).
UNLABELLED A toxicovenomic study was performed on the venom of the green mamba, Dendroaspis angusticeps. Forty-two different proteins were identified in the venom of D. angusticeps, in addition to the nucleoside adenosine. The most abundant proteins belong to the three-finger toxin (3FTx) (69.2%) and the Kunitz-type proteinase inhibitor (16.3%) families. Several sub-subfamilies of the 3FTxs wer...
متن کاملMuscarinic Toxins from Dendroaspis (Mamba) Venom
Jolkkonen, M., 1996. Muscarinic Toxins from Dendroaspis (Mamba) Venom: Peptides Selective for Subtypes of Muscarinic Acetylcholine Receptors. Acta Univ. Ups., Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 183. 52 pp. Uppsala. ISBN 91-554-3675-7 Snake venoms from various mamba species contain peptides which bind to the muscarinic but not to the nicot...
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عنوان ژورنال:
iranian biomedical journalجلد ۳، شماره ۱، صفحات ۵۳-۵۷
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